2018

When Change Is the Only Constant: The Promise of Longitudinal Neuroimaging in Understanding Social Anxiety Disorder

Haller, Simone P.W. and Mills, Kathryn L. and Hartwright, Charlotte E. and David, Anthony S. and Cohen Kadosh, Kathrin

10.1016/j.dcn.2018.05.005

Longitudinal studies offer a unique window into developmental change. Yet, most of what we know about the pathophysiology of psychiatric disorders is based on cross-sectional work. Here, we highlight the importance of adopting a longitudinal approach in order to make progress towards identifying the neurobiological mechanisms of social anxiety disorder (SAD). Using examples, we illustrate how longitudinal data can uniquely inform SAD etiology and timing of interventions. The brain’s inherently adaptive quality requires that we model risk correlates of disorders as dynamic in their expression. Developmental theories regarding timing of environmental events, cascading effects and (mal)adaptations of the developing brain will be crucial components of comprehensive, integrative models of SAD. We close by discussing analytical considerations when working with longitudinal, developmental data.

Cite this paper:

@article{hallerWhenChangeOnly2018,
  title = {When Change Is the Only Constant: {{The}} Promise of Longitudinal Neuroimaging in Understanding Social Anxiety Disorder},
  shorttitle = {When Change Is the Only Constant},
  author = {Haller, Simone P.W. and Mills, Kathryn L. and Hartwright, Charlotte E. and David, Anthony S. and Cohen Kadosh, Kathrin},
  year = {2018},
  month = oct,
  volume = {33},
  pages = {73--82},
  issn = {18789293},
  doi = {10.1016/j.dcn.2018.05.005},
  journal = {Developmental Cognitive Neuroscience},
  language = {en}
}